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JCO:健康飲食或能降低結直腸癌患者的死亡風險

日前,一項刊登在國際雜志Journal of Clinical Oncology上的研究報告中,來自美國癌癥協會的研究人員通過研究發現,遵循健康飲食的結直腸癌患者因結直腸癌和其它原因導致的死亡風險較低,即使是在確診癌癥后才開始改善飲食的患者依然如此。

日前,一項刊登在國際雜志Journal of Clinical Oncology上的研究報告中,來自美國癌癥協會的研究人員通過研究發現,遵循健康飲食的結直腸癌患者因結直腸癌和其它原因導致的死亡風險較低,即使是在確診癌癥后才開始改善飲食的患者依然如此。

圖片來源:CC0 Public Domain

目前在美國有140萬結直腸癌幸存患者,此前研究結果闡明了飲食質量對疾病預后的強烈影響,而且一些診斷前和診斷后飲食成分也與結直腸癌患者的生存直接相關;但對膳食結構分析來評估總體飲食質量與結直腸癌特異性死亡率之間關聯的研究結果卻并不一致,這就為結直腸癌幸存患者制定基于證據的指導建議變得非常困難了。

這項研究中,研究人員對來自美國癌癥協會大規模前瞻性癌癥預防-II期 (CPS-II)營養隊列研究中被診斷為結直腸癌的2801名男性和女性患者的數據進行分析,結果發現,那些在診斷前和診斷后飲食符合美國癌癥協會預防癌癥的營養和體力鍛煉指導方針的患者的全因死亡率和結直腸癌特異性死亡率通常較低。

相比不符合膳食指南的飲食模式而言,診斷前最接近美國癌癥協會飲食建議的飲食模式常常會降低患者22%的全因死亡率,而研究人員在結直腸癌特異性死亡率上觀察到了顯著的逆向趨勢,相比最低四分位組患者而言,診斷前遵循西方飲食模式的最高四分位組患者因結直腸癌導致的死亡風險會增加30%(西方飲食模式以大量攝入紅肉和其它動物產品為主要特征)。

患者診斷后的飲食模式也與其死亡風險密切相關,相比最低ACS評分(美國癌癥協會飲食評分)的患者而言,最高ACS評分的患者全因死亡率會降低38%,結直腸癌特異性死亡率會降低65%。研究者表示,額外的飲食模式和得分也是基于植物性食物和低水平的紅肉和加工肉類的攝入,而這一點也證實了他們的研究發現。

研究者總結道,本文研究結果闡明了飲食質量的重要性,因為其能作為一種潛在的可修飾工具來幫助改善結直腸癌患者的預后狀況。最后研究者Guinter說道,本文研究首次分析了飲食質量改變對于結直腸癌患者預后的影響,研究結果表明,癌癥診斷前后,高質量的飲食模式或與結直腸癌患者死亡風險降低直接相關。(生物谷Bioon.com)

原始出處:

Mark A. Guinter, Marjorie L. McCullough, Susan M. Gapstur, et al. Associations of Pre- and Postdiagnosis Diet Quality With Risk of Mortality Among Men and Women With Colorectal Cancer, Journal of Clinical Oncology (2018). DOI: 10.1200/JCO.18.00714

 
 
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