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J Oral Microbiol:好神奇!檢測下舌頭就知道是否患有胰腺癌!

近日,一項刊登在國際雜志Journal of Oral Microbiology上的研究報告中,來自中國浙江大學等機構的科學家們通過研究發現,舌頭上特定細菌水平的差異或能幫助有效區分早期胰腺癌患者和健康個體;盡管研究人員在胰腺癌患者機體的其它組織中發現了微生物組的破壞

近日,一項刊登在國際雜志Journal of Oral Microbiology上的研究報告中,來自中國浙江大學等機構的科學家們通過研究發現,舌頭上特定細菌水平的差異或能幫助有效區分早期胰腺癌患者和健康個體;盡管研究人員在胰腺癌患者機體的其它組織中發現了微生物組的破壞,但本文研究卻發現舌頭上微生物組的改變或能指示早期胰腺癌的發生;如果大規模的研究能證實該結果的話,研究人員未來或有望開發出早期胰腺癌的新型診斷技術。

圖片來源:Oleg Magni from Pexels

在英國每年大約有10000人會被診斷為胰腺癌,而僅有不到1%的患者存活超過10年,一種早期的診斷技術能有效改善患者成功治療的機會,但胰腺癌患者當出現癥狀或疾病進展時病情常常無法有效遏制,因此大多數病人在尋求幫助時常常已經進展到了晚期胰腺癌。目前研究人員正在尋找一些生物性改變來準確檢測胰腺癌的早期跡象,而如今研究者發現微生物組在癌癥的發生過程中扮演著關鍵角色。

這項研究中,研究人員招募了30名早期胰腺癌患者和25名健康個體,分析了參與者舌苔上的微生物組,參與者年齡在45-65歲之間,無其它疾病或口腔健康問題,在進行研究的前三個月里并未服用任何抗生素。研究者利用基因測序技術測定了參與者舌苔樣本中微生物組的多樣性,結果發現,相比健康個體而言,早期胰腺癌患者舌苔上存在著明顯不同的微生物組,研究者Lanjuan Li說道,盡管我們還需要后期的證實性研究,但本文研究結果證實了微生物組干擾/破壞與胰腺癌發生之間的關聯。

研究者表示,四種類型細菌的豐度或能幫助有效區分胰腺癌患者和健康個體,即低水平的嗜血菌屬和卟啉單胞菌屬,高水平的纖毛菌屬和梭桿菌屬。如果通過大規模的研究能夠證實細菌和胰腺癌之間的關聯,那么研究人員或許有望開發出基于微生物組的新型早期診斷技術;研究者推測,免疫系統或許是胰腺癌和微生物組改變之間關系的紐帶,比如胰腺疾病的發生或會以促進特定細菌生長的方式來影響機體免疫反應。后期研究人員希望通過進行更為深入的研究來開發有效預防人群胰腺癌發生的新療法。(生物谷Bioon.com)

原始出處:

Haifeng Lu, Zhigang Ren, Ang Li, et al. Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls, Journal of Oral Microbiology (2019) doi:10.1080/20002297.2018.1563409

 
 
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